In 2021, Christina Applegate was diagnosed with multiple sclerosis, a chronic condition that has thrown her life into a whirlwind of challenges. Recently, the beloved actress, now 52, opened up about her emotional struggles in a candid conversation on her podcast, "MeSsy," which she cohosts with Jamie-Lynn Sigler. "I’m in a depression right now, which I haven’t felt in years," Christina revealed, her voice tinged with vulnerability. "It’s like I’m trapped in this darkness that feels so heavy, and I can’t remember the last time I felt this way—probably over two decades ago."

Multiple sclerosis has not only brought physical pain into Christina’s life but also a deep emotional toll. The diagnosis has been a turning point for her, and she’s been grappling with the emotional weight of her new reality. Despite her strength and resilience, she admitted that the darkness feels overwhelming. "I’m so afraid to start crying because I’m worried I won’t be able to stop," she confessed. This fear has kept her from seeking therapy, even though she knows it could help her navigate the storm inside her mind.

However, she’s not alone in this battle. Jamie-Lynn, who has lived with MS for over 20 years, has been a rock of support for her friend. "Living with MS doesn’t mean you have to stop living," Jamie-Lynn encouraged her. "You still make me laugh harder than anyone else, and you bring so much joy and love into my life. You’re an incredible person, Christina, and you deserve to feel happy again." Her words were a reminder that even in the darkest moments, there’s always someone who believes in you.