When you think of the timeless show Little House on the Prairie, Michael Landon's name instantly comes to mind. The beloved actor and creator left an indelible mark on television history. But his legacy extends far beyond the screen. Michael Landon passed away in 1991 at the young age of 54 due to pancreatic cancer. Yet, his spirit continues to shine through his children, who are now carrying his torch by advocating for pancreatic cancer awareness. “My father is always in my daily thoughts,” shares daughter Leslie Landon Matthews in an exclusive interview with Closer. “He was a man of immense intelligence and generosity. And let’s not forget his brilliant sense of humor! Even when he faced pancreatic cancer, he kept a positive outlook on life. That’s the kind of strength we all aspire to have.”
Supporting the Fight Against Pancreatic Cancer
The Landon family has been deeply involved with the Pancreatic Cancer Action Network (PanCAN), a vital organization dedicated to raising awareness about this deadly disease. “We discovered PanCAN many years ago, and it’s been nothing short of extraordinary,” Leslie explains. “They don’t just provide resources for those battling pancreatic cancer; they also support families, conduct groundbreaking research, and offer a lifeline during one of the toughest times anyone can face.” PanCAN has become a beacon of hope for countless individuals, and the Landon family has embraced its mission wholeheartedly.
The Challenges of Pancreatic Cancer
Pancreatic cancer remains one of the most challenging cancers to diagnose and treat. It ranks as the third leading cause of cancer-related deaths in the United States, with a sobering five-year survival rate of just 13 percent. When Michael was diagnosed in 1991, the resources available were scarce. “Back then, we were flying blind,” Leslie recalls. “My brother Mike and I spent hours in libraries, searching through books and calling institutions to gather any information we could find about pancreatic cancer. It was a daunting task. Now, PanCAN offers a comprehensive resource that simplifies the process, making it easier for families to get the help they need.”
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Early Detection: The Key to Survival
Given the hereditary nature of pancreatic cancer, the Landon family has taken proactive measures to stay ahead of the disease. “Early detection is crucial,” emphasizes Michael Landon Jr.. “Tests like Grail are game-changers. They can screen not only for pancreatic cancer but also for over 50 other types of cancer. PanCAN strongly encourages anyone with a family history to undergo genetic testing to assess their risk.” The family’s vigilance has proven vital. Another sibling, director Christopher Landon, faced kidney cancer in his 40s. “We caught it early, and Chris is doing great now,” Leslie shares. “It’s a testament to the importance of staying informed and getting screened regularly, especially when cancer runs in your family.”

Recently, the Landon family formed “Team Little House” in honor of Michael for PurpleStride, PanCAN’s annual fundraising walk aimed at ending pancreatic cancer. This initiative serves as a tribute to Michael’s memory and a way to inspire others to join the fight. To contribute, visit purplestride.org. For more details on PanCAN and its mission to save lives, explore pancan.org or follow them on social media platforms like Twitter, Instagram, and Facebook.
For further insights into Little House on the Prairie and its 50th anniversary, including exclusive interviews with the cast and reflections on Michael’s legacy, pick up the latest issue of Closer, available May 10.

